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| | Personalized Treatment Trial for Breast Cancer Launched |
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date: May 24th 2006 10:45
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Research appearing online today in the Journal of Clinical Oncology** provides strong evidence for the value of using Oncotype DX™ to help women with this form of breast cancer determine whether they will benefit by adding chemotherapy to hormonal therapy. This study, as well as several other similar studies in recent years, provided the basis for the launch of TAILORx.
Breast cancer is the most frequently diagnosed cancer in women, with an estimated 212,920 new cases of invasive breast cancer expected in the United States in 2006. Over one-half of these women will have estrogen receptor positive, lymph node negative breast cancer. For 80 percent to 85 percent of those women, the current standard treatment practice is surgical excision of the tumor, followed by radiation and hormonal therapy. Chemotherapy is also recommended for most women, but the proportion of women who actually benefit substantially from chemotherapy is fairly small.
“A large number of these women are receiving toxic chemotherapy unnecessarily, and we need a means of identifying them,” said Jo Anne Zujeweski, M.D., senior investigator in the Clinical Investigation Branch of NCI’s Cancer Therapy Evaluation Program. “TAILORx could help change the way we treat breast cancer and improve the quality of patients’ lives, helping to better identify women who are likely to benefit from chemotherapy from those who are not.”
Oncotype DX™ measures the levels of expression of 21 genes (whether they are transcribed into messenger RNA) in breast tumors. This assessment can more precisely estimate a person’s risk of recurrence than standard characteristics, such as tumor size and grade. Based on the Oncotype DX™ gene expression analysis, a recurrence score from 0 to 100 is generated the higher the score, the greater a woman’s chance of having a recurrence if treated with hormonal therapy alone.
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article 'Personalized Treatment Trial for Breast Cancer Launched' source is National Institutes of Health - U.S. Department of Health, visit source site:
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